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Oct 2008;45(4):210-217

SAT1 activation can induce ferroptosis, while P53 can induce SAT1 transcriptional expression to promote lipid peroxidation and ROS-induced ferroptosis, and silencing SAT1 diminishes ROS-induced cellular ferroptosis in wild-type P53 cells [123, 124]

Extension of the native insulin-like growth factor-1 sequence by 13 amino acids and substitution of glutamic acid-3 with arginine produced a structurally distinct analogue central to IGF-1 receptor signalling studies

Also shown are the adverse clinical outcomes associated with elevated systemic TMAO levels in subjects, and enhanced cardiometabolic phenotypes observed with elevated TMAO levels in animal models (46, 12, 13, 1618)