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Earlier studies have shown that in healthy volunteers, daily doses of VitC exceeding 500 mg tend to decrease its bioavailability

This polarity is critical for controlling the movement of hydrophilic substances such as glucose, amino acids, metals, and drugs (Maiuolo et al., 2018

Broadly, mitochondrial-driven diseases can be classified into two categories: i) primary mitochondrial diseases, which stem from direct genetic mutations of mtDNA or nDNA encoding for proteins expressed in the mitochondria and ii) mitochondrial dysfunction associated with complex diseases, observed in systemic conditions such as diabetes (Yoon et al., 2011 February 1), ischemia reperfusion injury (Figure 1)

Further studies are needed to elucidate the mechanisms underlying these important potential differences