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Fatigue, liver enzyme elevation, tremors, mood changes, and Kayser-Fleischer rings are common early signs

10.1007/s10549-020-05702-6 142 WuS.RheeK.-J.AlbesianoE.RabizadehS.WuX.YenH.-R.et al (2009)

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In patients with HBV infection, secukinumab showed good efficacy, but periodic monitoring of liver function is recommended as reactivation of HBV has been observed, particularly in susceptible individuals, with a reported reactivation rate of 15.2% in psoriasis patients (Chiu et al