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[18,19] While a rigorous characterization of senescent cells in vitro can generally be obtained by multiplexing three or more of these consensual markers, quantification of senescence in vivo is often complicated by the fact that tissue homogenates are composed of varied cell types and expression levels, among which senescent cells account for a relatively small percentage

Historical Background and Scientific Context Scientific interest in peptide signalling compounds expanded significantly during the late twentieth century as advances in peptide chemistry enabled researchers to investigate increasingly complex molecular communication systems