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Moon JS, Karunakaran U, Elumalai S, Lee IK, Lee HW, Kim YW, et al

However, in some cases the immune reaction continues, leading to an excessive inflammatory response often referred to as a cytokine storm. In an effort to define some of the key players in SARS-CoV-2-associated cytokine storms, a group in France analyzed the cytokine responses in fifty COVID-19 patients experiencing varying disease severity

It is driven by iron-dependent phospholipid peroxidation and regulated by several cellular metabolic events, including redox homeostasis, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars [67]

The remaining tissue samples were stored at 80 C for further analysis