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Maintaining an optimal level of glutathione appears to be important for supporting cognitive function, especially during aging.* The normal process of aging is associated with a decrease in glutathione activity, which can result in increased oxidative activity.* Less than an optimum level of glutathione is observed in individuals experiencing a decline in cognitive function.* Conversely, individuals who live to 100 tend to have higher glutathione activity.* Although a common mistaken belief is that glutathione is not well absorbed when it's taken orally, significant data confirms that glutathione is efficiently absorbed across the intestinal epithelium by a specific uptake system.* *These statements have not been evaluated by the Food and Drug Administration

Thus, the increase in methionine amount that was induced by inhibiting TNAP would increase CDO activity, leading to increased concentration of hypotaurine and taurine

10.1016/j.cmet.2025.04.008 37 NiuQ.MouY.YaoY.DongH.WangK.ZengZ.et al (2025b)

Ries S , Gonagunta A, Baikh JY, Singhi EK, Antonoff MB