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10.1371/journal.pone.0130908 111 QiuY.XuS.ChenX.WuX.ZhouZ.ZhangJ.et al (2023)

Considering the pharmacokinetics of human growth hormone (hGH), the common practice of administering subcutaneous human growth hormone (hGH) injections in the evening between 20:00 and 21:00 leads to a peak in hormone levels approximately 46 hours later, aligning closely with the natural nocturnal surge that typically occurs around midnight to 02:00 ( Switching to morning GH injections would indeed alter this pattern, causing higher circulating GH levels during daytime hours than under normal physiological conditions

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Cytokine release syndrome is one of the safety concerns associated with this novel treatment approach [45, 50]