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Additionally, it can be hard to get an accurate representation of nutrient status solely based on blood levels, as we want to look inside of the cell to truly understand if someone has enough of that nutrient for optimal function of the cell

Circadian clock control by polyamine levels through a mechanism that declines with age

8 and Supplementary Table 1)

Excessive ROS generated by the electron transport chain damages mitochondrial membranes, proteins, and DNA, while impaired calcium handling increases cytosolic and mitochondrial Calcium (Ca 2+) levels, further compromising bioenergetics ( 2+ overload enhances ROS production by stimulating dehydrogenases and destabilizing ETC function