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484 Recent research has highlighted the role of immune dysregulation in diabetic focal neuropathies, with nerve biopsies revealing inflammatory infiltrates that suggest potential benefits from immunosuppressive therapies

This is particularly crucial when normal glucose metabolism is impaired, a phenomenon frequently observed in neuroinflammatory conditions

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The mechanisms of action of the indirect methods have been amply discussed [131] and the therapeutic benefit is almost 80% for the direct procedure and about 73% for the chemical acupuncture