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10.1038/s41586-019-1705-2 8 Bosello-TravainV.ConradM.CozzaG.NegroA.QuartesanS.RossettoM.et al (2013)

After the first clinical report of APAP toxicity [22], investigators at the US National Institute of Health developed a mouse model of APAP-induced hepatotoxicity, which mimicked the serious liver injury observed in humans [79]

In addition, compelling evidence suggests that DNA damage response (DDR) signaling is a predominant mechanism associated with the build-up of DNA damage, aging, and cell senescence (Malaquin et al., 2015)