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Because sulfoxide metabolites are more potent nephrotoxicants than their parent S -conjugates, more research is needed on the extent of formation of S -(1,2-dichlorovinyl)-L-cysteine and N -acetyl- S -(1,2-dichlorovinyl)-L-cysteine sulfoxides by human tissues (liver and kidney), the extent to which these reactions occur in vivo, the enzymes involved, and their interindividual variability, including the role of genetic polymorphisms

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Front Surg 8: 683041

Choi KR, Yu HE, Lee H, Lee SY (2022) Improved production of heme using metabolically engineered Escherichia coli