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The clinical implications of altitude-induced oxidative stress are not entirely clear [85, 86], beyond being linked to acute mountain sickness (AMS) at high altitudes [87, 88]

A systematic review and meta-analysis concluded that long-term supplementation with selenium had no effect on thyroid hormone levels or symptoms for hypothyroid patients

Gestating and lactating mares, young growing horses, and performance horses have the greatest need for vitamin E supplementation, especially those that do not have access to lush, green pasture

IRAK4 degraders may address this issue, and the development and application of these drugs will be a focus in the coming years