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Here are 15 high-risk interactions every healthcare professional must remember: 1 Warfarin + NSAIDs Bleeding risk 2 ACE inhibitors + Potassium Hyperkalemia 3 SSRIs + MAOIs Serotonin syndrome 4 Metformin + Contrast dye Lactic acidosis 5 Digoxin + Diuretics Toxicity 6 Clopidogrel + Omeprazole Reduced effect 7 Lithium + NSAIDs Lithium toxicity 8 Theophylline + Ciprofloxacin Toxicity 9 Statins + Macrolides Myopathy risk Sildenafil + Nitrates Severe hypotension 11 Insulin + Beta-blockers Masked hypoglycemia 12 Methotrexate + NSAIDs Toxicity 13 Rifampicin + OCPs Contraceptive failure 14 Antacids + Tetracycline Reduced absorption 15 Carbamazepine + Phenytoin Altered drug levels Always review medications before prescribing prevention is better than cure