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3.7 Other PCT substances identification All results are summarized in Table 2

Hum Mol Genet 14:27492755 Gao Y, Peterson S, Masri B et al (2015) Cariprazine exerts antimanic properties and interferes with dopamine D2receptor -arrestin interactions

They interact directly with the cellular signaling pathways that govern mast cell degranulation, effectively calming these hyper-reactive cells and reducing the systemic burden of histamine