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Examples of these different effects are: p53 activation by DNA damage resulting in death (apoptosis) of human fibroblasts

doi: 10.1016/j.cellsig.2006.12.009 430 DehghanianFSoltaniZKhaksariM

Taking into account the considerations mentioned above on vitiligo, it is evident that besides the genetic or constitutional susceptibility, there might be also a secondary issue associated with vitiligo which is the psychological and emotional susceptibility strongly felt by individuals permanently affected by the disease