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instillation to vehicle, 0.2 g (low-dose) or 1.0 g (high-dose) of LPS once a week for four weeks (n = 3 mice/group)

PMCID: PMC5133058

Shih et al., 2000) to avoid the mono-ubiquitination of substrates that would otherwise shunt them to the endosomal-lysosome pathway to be degraded (Osaka et al., 2003)