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As animals have adapted to rely on external sources of thiamine, their genes have changed to reflect this dependence [6]

[4] Blood level monitoring is recommended to decrease the risk of potential toxicity

Mice 10 to 12-month-old (unless otherwise stated) heterozygous 5xFAD female mice on a mixed C57BL/6 and SJL genetic background (Tg6799, MMRRC_034840-JAX

Additionally, transgenic mice used as a model of AD disease were shown to have reduced BRCA1 levels, an important DNA repair factor, which was accompanied by an increase in DSB and synaptic impairments, among other symptoms associated to AD (Suberbielle et al., 2015)