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ER stress contributes to PD pathology through multiple mechanisms, including protein aggregation, apoptosis, oxidative stress, inflammatory responses, mitochondrial dysfunction, and autophagy disorders, all of which promote dopaminergic neuron loss and disease progression (Fig

Additionally, hyponatremia-induced reduction in extracellular osmotic pressure and resultant cerebral edema are deemed significant contributors to hepatic encephalopathy development, with a reported 8% increase in hepatic encephalopathy risk for every 1 mmol/L reduction in serum sodium (Iwasa and Takei, 2015

And in many ways it is

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