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Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease

Clinical Update 7/01/2022 Potassium for Arthritis

Several factors combine: absence of active patent (thus little pharmaceutical incentive to finance trials), ambiguous regulatory status in most countries, high cost of a phase I to III clinical trial (several million to tens of million euros), difficulty in defining a precise indication acceptable to a regulatory authority

Safety screening should consider thyroid cancer history, multiple endocrine neoplasia type 2, pancreatitis, gallbladder disease, kidney disease, severe stomach-emptying problems, diabetic eye disease, eating disorders, pregnancy plans, and breastfeeding