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Abbreviations VEGF: Vascular endothelial growth factor ADSC: Adipose derived stromal cells ECFC: Endothelial colony forming cells, HUVEC, Human umbilical vein endothelial cells NHDF: Normal human dermal fibroblasts EGF: Epidermal growth factor FGF: Fibroblast growth factor BM: Basal media SMA: Smooth muscle actin PDGFR-: Platelet derived growth factor receptor beta HGF: Hepatocyte growth factor, Bev, Bevacizumab Ram: Ramucirumab GSI: Gamma secretase inhibitor