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Another mechanism by which KD affects mitochondria is by increasing the expression of uncoupling proteins (UCPs) [40], which are located in the inner mitochondrial membrane

This localization theoretically reduces systemic side effects and cancer concerns compared to long-acting analogs, though local effects may still influence surrounding tissues

Beyond the approval of different botulinum toxin preparations for the treatment of sialorrhea, efforts to address the plethora of non-motor symptoms of the disease have not translated to novel PD-specific approvals over the last few years

Potential side effects of L-carnitine supplementation include: Nausea Vomiting Stomach cramps Diarrhea A fishy body odor Muscle weakness in people with chronic kidney disease An increased risk of seizures in people with a seizure disorder Additionally, Tallent says L-carnitine supplementation may also elevate trimethylamine-N-oxide (TMAO) blood levelsa risk factor for atherosclerosis, the medical term for clogged arteries