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HPLC purity, LC-MS identity, disulfide bond integrity, and LAL endotoxin readings are scored against pre-locked specifications, and full pass across all four assays is required before any lot is cleared into saleable inventory

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doi: 10.1136/thx.2008.105080 13 GentileJHSparoMDMercapideMELunaCM

Zinc signaling is essential for NETosis, as zinc chelation by TPEN inhibits this process without affecting PKC activity or ROS production, suggesting zinc acts downstream of ROS [161]