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Description

Nat Chem Biol 21 , 779789 (2025)

These results are in accordance with the finding of gene ontology terms for GPX7 -co-expressed genes being related to stromal reactions (e.g.: immune cell infiltration and IFN-I response) in LGG, but being mainly related to metabolic processes in GBM, suggesting that while in LGG GPX7 activation directly impacts the tumor microenvironment, in GBM the affected processes are tumor-cell intrinsic