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Later, it was discovered that mitochondrial DNA encodes its own small biologically active peptides that are released from the mitochondria and act as hormone-like signaling molecules throughout the body

For this reason, MOTS-c is thought of as an exercise mimetic and has been linked to metabolic improvements and increased insulin sensitivity

In 1973, Loren Pickart and Margaret Thaler reported that a small factor in human serum could prolong the survival of normal liver cells and modulate growth in liver tissue, and that plasma from younger donors was more active than plasma from older donors