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Moreover, additional concerns were raised from preclinical studies suggesting that complete blockade of intratumoral blood flow could result in extreme hypoxia within the TME, which could accelerate local invasion and distant metastases of tumor cells and even induce severe immunosuppression within the TME 34

High-dose amino acid infusion preserves diuresis and improves nitrogen balance in non-oliguric acute renal failure

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169 Molecular mediators that drive organ crosstalk Interorgan crosstalk among the kidney, heart, brain, adipose tissue, liver, skeletal muscle, pancreas, and intestine plays a pivotal role in the development of insulin resistance and -cell dysfunction, which are central to the progression of diabetic complications