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Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA

8 weeks at ~200 mcg/day: ~2 vials 12 weeks at ~200 mcg/day: ~2 vials 12 weeks at ~300 mcg/day: ~3 vials Insulin Syringes (U-100, 1 mL) Per week: 7 syringes (1/day) 8 weeks: ~56 syringes 12 weeks: ~84 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 10 mg vial for reconstitution

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We quantitatively compare energy efficiencies across synthesis routes: one-step carbonization-activation reduces energy intensity by 4050% compared to sequential multi-step protocols, though often at the expense of structural precision