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Thus, CRISPR/Cas9-based gene therapy has reached the clinical trial stage for many monogenic diseases such as sickle cell anemia [7], -thalassemia [7], hereditary tyrosinemia type I [8] and is being applied in advanced preclinical testing stages of Duchenne muscular dystrophy (DMD), hemoglobinopathies, and hereditary tyrosinemia type I

Research demonstrates that carnosine can inhibit the secretion of tumor necrosis factor- (TNF-) and interleukin-6 (IL-6), among other inflammatory mediators, thereby reducing inflammation (21-24)

Recent developments include dual-targeted liposomes, which employ two different ligands to recognize multiple tumor-specific receptors, thereby enhancing targeting accuracy in complex tumor microenvironments

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