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My GP had my serum B12 retested and my serum MMA tested: as she suspected, I had functional B12 deficiency, a diagnosis confirmed by the testing laboratory, which means that high levels of both in the bloodstream are due to them not making the connection necessary to transport the B12 to cells and tissues

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[DOI] [Google Scholar] Tohei A

The most common method, also introduced by Schilling, is to inject a high dose of unlabeled B12 to saturate all binding capacities of the B12 binding proteins, and thereby facilitating urinary excretion of the absorbed radioactively labeled B12