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Lancet Neurol (2017) 16(3):20816

A more recent review also cites sulfonamides, phenytoin, phenothiazines, phenylbutazones and derivatives, imipramines and derivatives, proquazone, and pyrimethamine (Dash et al., 2021)

Molecular docking has identified glutamate dehydrogenase 2 (GLUD2) as a key target, with 27 bioactive THH components (wilforine, wilfordine) binding strongly to its active site (PDB ID: 6G2U)