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however, the current evidence base is constrained by notable limitations

Although a relatively higher prevalence of comorbid conditions, such as DM and HTN, which are well-known risk factors of CKD progression, has been reported among the patients with RA (11), the result from the subgroup analyses in the current study suggests that RA is directly, rather than the aggravation of underlying comorbidities, associated with the progression of CKD, as the association of RA with the risk of ESRD was significantly stronger among those without obesity, DM, HTN, DL, or CKD

doi: 10.1016/j.cytogfr.2018.08.004 190 MirfakhraieRNoorazarLMohammadianMHajifathaliAGholizadehMSalimiMet al

Long-term safety data for high-dose supplementation in healthy aging populations remains limited