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doi: 10.3390/microorganisms9051021 303 EzejiJCSarikondaDKHoppertonAErkkilaHLCohenDEMartinezSPet al

Significance of HTL The metabolic conversion of Hcy to HTL, the reactive anhydride of Hcy was proposed by Jakubowski in 1997 [47]

Through its active metabolite, calcitriol, it binds to the VDR expressed on macrophages, dendritic cells, natural killer cells, and T and B lymphocytes, thereby mediating antimicrobial activity, cytokine balance, Tcell polarization, and immune tolerance, effects that extend far beyond classical mineral metabolism and frame vitamin D as an endogenous immunomodulator [66]