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Preclinical evaluation of the CDK4/6 inhibitor palbociclib in combination with a PI3K or MEK inhibitor in colorectal cancer

Cell 2012;148(12):21327

Ueda S, et al

Both mAbs significantly reduced footpad swelling compared to the PBS-treated animals, although relative weight change was not significant after day 2 post-administration of mAbs or PBS (Fig