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We then unveiled how the mutation affects endothelial progenitor cells and impacts angiogenesis and endothelial stability, revealing how the liver niche plays a significant role in ALGS-related liver disease and explaining some of the systemic manifestations of the syndrome

Interestingly, a study found that mutations in CHCHD2 in fibroblasts from PD patients lead to fragmentation and reduced OXPHOS activity of complexes I and IV [104]