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During exercise, the accumulation of metabolites results in exercise fatigue, inflammation and trauma

SUMMARY OF THE DISCLOSURE [0008] Without being bound to a particular theory, the inventors hypothesized that RSLs, such as erastin, activate a lethal pathway that is different from apoptosis, necrosis and other well-characterized types of regulated cell death

Overall, this investigation should provide guidance and support for current and future pharmaceutical development efforts against mycobacterial pathogenesis