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Over the years, numerous studies have highlighted the critical role of DNA methylation in the progression from precancerous conditions, such as cervical intraepithelial neoplasia (CIN), to CESC [261,262,263]

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Researchers may examine inflammatory markers and cytokine-related pathways in controlled experimental models

These postmortem results, along with those from the current and our previous study that highlighted a considerable number of differentially serum expressed amino acids between cases and controlsespecially in malessupport the idea that PD is a heterogeneous systemic disease that disrupts metabolic homeostasis across both central and peripheral organs (Costa et al., 2023)