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Thiele et al., 2022) and the Default Mode Network (DeSerisy et al., 2021

10.14800/ttnd.243 199 KandelE

Glutamatergic signaling deficits are regarded as one of the earliest neurodevelopmental abnormalities associated with SCZ, with primary deficits in NMDA-R signaling, particularly in layer 3 pyramidal neurons in prefrontal cortex ( Finally, in consideration of the well-known role in motivation and incentive behavior, the DA hypothesis provides a reasonable neurobiological substrate to the salience hypothesis ( Dopaminergic Dysfunctions Relevant to Negative Symptoms As outlined above, NS are heterogeneous

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