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Moreover, Study conducted on mouse model reported that LPS can downregulate occluding (a protein in tight junction) in the intestinal epithelial cells and upregulate TNF-, which promotes the expression of -synuclein ( Several research studies suggested that altered GM plays a crucial role in accelerating oxidative stress, inflammation and DNA damage

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Nature 610 , 381388 (2022)

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Stcker S, Van Laer K, Mijuskovic A, Dick TP

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