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Given this evidence an in-depth understanding of ferroptosis mechanisms involved in the occurrence and development of AD is needed to facilitate timely diagnosis and treatment before major brain damage occurs, improving the survival rate and quality of life of AD patients

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Furthermore, it has been suggested that cell damage may result in high plasma glutamine, due to leakage of intracellular glutamine from the destroyed cells into plasma [10], as intracellular glutamine concentrations greatly exceed plasma concentration in many tissues [25,26,27,28]

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