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We cross-referenced coimmunoprecipitation and proximity labeling data sets, which accounted for three different NHR-49 strains including the overexpressed all-tissue NHR-49::GFP under fed and fasted conditions 42 and the endogenous N- and C-terminal TurboID tagged NHR-49 48

From now on in the text, every time the iSM454 model is mentioned, it will refer to the model in which the S matrixes are included

PPE promotes osteoblast differentiation and proliferation, inhibits osteoclast activity, and exhibits significant anti-inflammatory and antibacterial properties, enabling it to accelerate tissue repair and reduce inflammatory responses