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An increase in the level of free oxygen radicals may cause mutagenicity, cytotoxicity, and changes in gene expression, leading to the development of malignant tumors, and this mutagenicity may contribute to the transformation of benign development into malignant [41]

National Institute of Health grants P01 CA120964 (to L.C.C.), R35-CA197588 (to L.C.C.), P01-CA117969 (to L.C.C.), R35-ES028374 (to M.B.Y.), R01-CA226898 (to M.B.Y.), R01-GM135331 (to B.E.T.) and R01-GM104047 (to B.E.T