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However, artificial overexpression of IGF-1R in vitro does result in malignant transformation ( TP53, BRCA1 , von-Hippel Lindau protein and Wilms tumour-1 (Werner, 2012)

Gynecomastia (rare, reported in male adolescents): Proposed mechanism involves GH-driven aromatase activity increasing estradiol

Observations in rodent studies suggest that increases in bone mineral content may reflect structural adaptations, rather than changes in volumetric bone density