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These in vitro models offer new tools to explore the molecular mechanisms of the early embryo-endometrium interaction and to bypass the barrier of ethical restrictions

Most attention has focused on the ascorbate-glutathione pathway, but several other candidate pathways may couple the availability of oxidants such as H 2 O 2 to changes in glutathione and thus impact on signaling pathways through regulation of protein thiol-disulfide status

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Moreover, several studies have documented heightened markers of oxidative stress during acute COVID-19, as well as increased concentrations of MDAa key indicator of lipid peroxidationin individuals with post-COVID-19 condition 22,23