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Zinc is critical to a diverse group of physiological processes, such as immune function, insulin signaling, tissue repair, vision and neuro-transmission

Like pocket 1, the two smaller pockets 4 and 5 exhibit both hydrophobic and polar residues that interact with the phenyl ring and mainchain atoms (Fig

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doi: 10.1002/art.41748 201 GrlachADieboldISchini-KerthVBBerchner-PfannschmidtURothUBrandesRPet al