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While there are no extensive RCTs data that discredit the association of irAEs with good clinical outcomes, a landmark analysis of a retrospective review of only 97 patients showed no difference in OS at 3 months in patients on single-agent ICI, even though the incidence of irAEs was associated with an OS (24.3 versus 5.3 months

Adipose tissue macrophage burden, systemic inflammation, and insulin resistance

Alexandra Naba Author profile: Nature Reviews Molecular Cell Biology author profile (Alexandra Naba) Alexandra Naba is a research author whose work on the extracellular matrix (ECM) informs broader discussions of cellular environments, matrix composition, and structural frameworks that can intersect with laboratory peptide research contexts