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Most newer drugs have a broader spectrum of activity, and many are well tolerated

19 However, therapeutic goals during early-stage CD differ considerably compared with treatment goals for late-stage disease

synthesized by certain bacteria Although the intestinal flora of humans is able to synthesize vitamin B 12 , humans are not able to absorb bacteria-generated vitamin B 12 since the location of synthesis (the colon) is too distal from the location of absorption (the small intestine)

Donor HCV status (HR=1.99, CI 0.23-17.1, p= 0.53), age at transplant (HR=1.00, CI 0.95-1.07, p=0.91), sex (HR=0.44, CI 0.05-3.73, p=0.45), and LVAD usage (HR=0.83, CI .015-4.52, p=0.83) were not associated with risk of death due to primary graft dysfunction