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Conclusion In conclusion, this review systematically analyzes the PD/PK mechanisms by which herbs influence ACDs and summarizes current predict methods for HDI risks, aiming to promote these predictive approaches to address existing limitations in HDIs research

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Besides, for natural compounds like saikosaponins and cynaroside, pharmacokinetics are the major concerns that must be addressed through formulation engineering or delivery strategies

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Rather, Epitalon may act like a molecular locksmith, loosening tightly wound regions of DNA, allowing previously silenced genes, such as those involved in antioxidant defenses or DNA repair, to reawaken

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