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AOD 9604: Chemical Identity AOD 9604 is a synthetic growth hormonederived peptide fragment corresponding to the C-terminal lipolytic region of human GH, with an additional N-terminal tyrosine residue incorporated to improve structural stability in laboratory systems

Questionnaires Food diaries were maintained throughout the study by participants

They proposed that melatonin upregulates antioxidant enzymes, increases distribution of cells in S-phase and decreases G0/G1 cells, reduces lipid peroxidation, all of which could explain its protective mechanism [39]

Necroptosis, driven by the RIPK1RIPK3MLKL signaling cascade, is amplified in the presence of ROS, leading to the formation of membrane pores and membrane rupture, which releases inflammatory molecules and additional ROS