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Common Injectable Cycle Patterns Approach Conservative start Daily dose 1.0 mg Schedule 5 days on / 2 off Cycle length 4 weeks Approach Standard Daily dose 1.0-1.5 mg Schedule Daily Cycle length 4-6 weeks Approach Higher end Daily dose 1.5-2.0 mg Schedule Daily Cycle length 6-8 weeks Educational reference

Well-designed, placebo-controlled human trials are necessary to confirm the efficacy, safety, and appropriate dosing regimens of AP for conditions such as asthma, dysmenorrhea, erectile dysfunction, and gastrointestinal or vascular disorders

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More recently, Langston et al reported that in human brain endothelial cell line, insulin activated GCLC promoter activity under altered glycemic condition (both low and high) that required PI3K/Akt/mTOR signaling [70]