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Furthermore, inhibition of Rac1 activity by Rhein not only reduces oxidative stress but also affects downstream signaling pathways involved in EMT and renal fibrosis, such as the -catenin pathway (Xiong et al., 2023)

Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy

Moreover, antioxidants quercetin (QE), baicalein (BE) and myricetin (ME) effectively downregulated ROS and MMP9 and inhibited glioma cell invasion/migration events in vitro ( However, some studies have shown that intake of antioxidants, such as carotenoids (371), vitamin E (372), and coffee (373), is not associated with the risk of developing gliomas

Recently, it has been reported that oral administration of 1 g/day of vitamin C for a period of 16 weeks resulted in the reduction of serum levels of malondialdehyde and elevation of glutathione peroxidase levels among the patients on maintenance hemodialysis (34)