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The elevated IGF-1 environment drives protein synthesis and lean mass accretion while the GH-mediated lipolysis preferentially mobilizes visceral and subcutaneous fat, particularly in the abdominal region

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Finally, we briefly describe how the GH/IGF-I axis is impacted by liver disease, weight loss, GH misuse for recreational and athletic performance-enhancing, GH-releasing hormone (GHRH) analog use in HIV lipodystrophy, and the alterations of the GH/IGF-I axis in subjects with congenital isolated GH and IGF-I deficiencies